|
KMID : 0381019870200060432
|
|
Korean Journal of Nutrition
1987 Volume.20 No. 6 p.432 ~ p.441
|
|
|
Effects of Alcohol Consumption and Fat Content in Diet on Growth, Hepatic Function and Biochemical Indices of Blood in Rat
|
|
|
|
|
Abstract
|
|
|
This study was undertaken to investigate effects of alcohol and fat content in a balanced diet on growth, hepatic function and some biochemical indices of blood in growing rats. Fourty eight male rats of Sprague-Dawley strain weighing about 1608 were divided into 4 groups : high fat diet group, alcohol-administered high fat diet group, low fat diet group and alcohol-administered low fat diet group. High and low fat diet supplied 30 % and 12 %, respectively, of total calorie intake from fat and alcohol-treated groups received water containing 10% ethanol. Diets contained adequate amounts of all nutrients required for rats, including lipotropic agents (choline and methionine) to minimize effects of factors other than alcohol on liver function. Growth rate was lowest in alcohol-administered low-fat diet group, despite that their energy intake was equivalent to the others. For a 3-week study period, 21.86 % and 23.61 % of total calorie intake were derived from alcohol in alcohol-administered high fat diet group and low fat diet group, respectively.
There was no influence on vitamin B1 status by alcohol consumption.
Concentation of triglyceride in plasma increased with alcohol comsumption, and the effect was greater after 6 weeks than after 3 weeks of alcohol consumption. Difference of dietary fat content did not affect the level of triglyceride. The levels of total cholesterol and HDL-choleste-
rol in plasma were not influenced by alcohol consumption. Serum glutamate pyruvate transaminase activity and hepatic mitochondrial respiration rate did not differ between groups. The results indicate that neither moderate alcohol drinking for 6 weeks nor fat content with a balanced diet caused any dramatic change of metabolism and liver function in rats. However they suggest that even moderate alcohol consumption can affect growth of animals dramatically and the effect may be lessened with relatively high fat content in diet.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|